Thiomorpholine → HCID 131724188, compound

HRID 478436Notes

Reaction equation

HRID 478436 reaction equation
C([N:8]1[CH2:13][CH2:12][C:11](=O)[CH:10]([C:15]2[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=2)[CH2:9]1)C1C=CC=CC=1.[NH:22]1[CH2:27][CH2:26][S:25][CH2:24][CH2:23]1.[F:28][C:29]([F:44])([F:43])[C:30]1[CH:31]=[C:32]([CH:36]=[C:37]([C:39]([F:42])([F:41])[F:40])[CH:38]=1)[C:33](Cl)=[O:34]>>[F:28][C:29]([F:44])([F:43])[C:30]1[CH:31]=[C:32]([C:33]([N:8]2[CH2:13][CH2:12][C@H:11]([N:22]3[CH2:27][CH2:26][S:25][CH2:24][CH2:23]3)[C@H:10]([C:15]3[CH:16]=[CH:17][C:18]([CH3:21])=[CH:19][CH:20]=3)[CH2:9]2)=[O:34])[CH:36]=[C:37]([C:39]([F:42])([F:41])[F:40])[CH:38]=1

Participants

4

Reactant 3

HCID 67164ThiomorpholineHCID 1018563,5-Bis(trifluoromethyl)benzoyl chlorideHCID 18001148HCID 18001148, compound

Product 1

HCID 131724188HCID 131724188, compound

Procedure

The title compound, MS: m/e=517.3 (M+H+), was prepared in accordance with the general method of example 26 from 1-benzyl-3-(4-methyl-phenyl)-piperidin-4-one, thiomorpholine and 3,5-bistrifluoromethyl-benzoyl chloride.

Sources & evidence

ORD record
ord-9d71e44dd47640a786c7c873d2d1582e
Source dataset
uspto-grants-2003_11
Patent number
US06642226B2

Reaction notes

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