3,5-Bis(trifluoromethyl)benzoyl chloride → HCID 131724189, compound

HRID 478437Notes

Reaction equation

HRID 478437 reaction equation
C([N:8]1[CH2:13][CH2:12][C:11](=O)[CH:10]([C:15]2[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=2)[CH2:9]1)C1C=CC=CC=1.[CH3:22][C@H:23]1[O:28][C@@H:27]([CH3:29])[CH2:26][NH:25][CH2:24]1.[F:30][C:31]([F:46])([F:45])[C:32]1[CH:33]=[C:34]([CH:38]=[C:39]([C:41]([F:44])([F:43])[F:42])[CH:40]=1)[C:35](Cl)=[O:36]>>[F:30][C:31]([F:46])([F:45])[C:32]1[CH:33]=[C:34]([C:35]([N:8]2[CH2:13][CH2:12][C@H:11]([N:25]3[CH2:26][CH:27]([CH3:29])[O:28][CH:23]([CH3:22])[CH2:24]3)[C@H:10]([C:15]3[CH:16]=[CH:17][C:18]([CH3:21])=[CH:19][CH:20]=3)[CH2:9]2)=[O:36])[CH:38]=[C:39]([C:41]([F:44])([F:43])[F:42])[CH:40]=1

Participants

4

Reactant 3

HCID 1018563,5-Bis(trifluoromethyl)benzoyl chlorideHCID 6415002,6-Dimethylmorpholine, cis-HCID 18001148HCID 18001148, compound

Product 1

HCID 131724189HCID 131724189, compound

Procedure

The title compound, MS: m/e=529.3 (M+H+), was prepared in accordance with the general method of example 26 from 1-benzyl-3-(4-methyl-phenyl)-piperidin-4-one, cis-2,6-dimethyl-morpholine and 3,5-bistrifluoromethyl-benzoyl chloride.

Sources & evidence

ORD record
ord-1c7be61cae814107acc087d1f52c4e4e
Source dataset
uspto-grants-2003_11
Patent number
US06642226B2

Reaction notes

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