Ethanolamine → HCID 10119214, compound

HRID 478446Notes

Reaction equation

HRID 478446 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([CH:14]2[CH2:19][CH2:18][N:17]([C:20](=[O:35])[C:21]3[CH:26]=[C:25]([C:27]([F:30])([F:29])[F:28])[CH:24]=[C:23]([C:31]([F:34])([F:33])[F:32])[CH:22]=3)[CH2:16][CH:15]2[C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.N[CH2:43][CH2:44][OH:45]>C(Cl)(Cl)Cl>[F:30][C:27]([F:28])([F:29])[C:25]1[CH:26]=[C:21]([C:20]([N:17]2[CH2:18][CH2:19][CH:14]([N:11]3[CH2:12][CH2:13][N:8]([CH2:43][CH2:44][OH:45])[CH2:9][CH2:10]3)[CH:15]([C:36]3[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=3)[CH2:16]2)=[O:35])[CH:22]=[C:23]([C:31]([F:33])([F:34])[F:32])[CH:24]=1

Participants

4

Reactant 2

HCID 700EthanolamineHCID 86586143HCID 86586143, compound

Product 1

HCID 10119214HCID 10119214, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The title compound, MS: m/e=530.3 (M+H+), [α]58920=−8.02, [α]54620=−5.61, [α]43620=−20.05, [α]36520=−59.35 (c 0.1247, chloroform), was prepared in accordance with the general method of example 114 from (−)-4-[1-(3,5-bis-trifluoromethyl-benzoyl)-3-phenyl-piperidin-4-yl]-piperazine-1-carboxylic acid tert-butyl ester and 2-amino ethanol.

Sources & evidence

ORD record
ord-59c36f4a3c6e42778cc8f95f765ec427
Source dataset
uspto-grants-2003_11
Patent number
US06642226B2

Reaction notes

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