HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylpiperazine → Rac-cis-(3,5-difluoro-phenyl)-[4-(4-methyl-piperazin-1-yl)-3-phenyl-piperidin-1-yl]-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | 3,5-Difluorobenzoyl chloride | HCID 145600 | — |
| Reactant | 1-Benzyl-3-phenylpiperidin-4-one | HCID 11817956 | — |
| Product | Rac-cis-(3,5-difluoro-phenyl)-[4-(4-methyl-piperazin-1-yl)-3-phenyl-piperidin-1-yl]-methanone | HCID 131724195 | — |
Reaction Steps
The title compound, MS: m/e=400.5 (M+H+), was prepared in accordance with the general method of example 26 from 1-benzyl-3-phenyl-piperidin-4-one, N-methyl-piperazine and 3,5-difluoro-benzoyl chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06642226B2 |
| Source dataset | uspto-grants-2003_11 |
| ORD ID | ord-9d51d774dc6d499b91c7e44082d3d8fe |
| Source note | uspto-grants-2003_11 |