反应详情

A suspension of 1 g (2.61 mmol) of 7-benzylthio-3-(2-chlorophenyl)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one in 10 mL of dichloromethane was cooled in ice and treated with 1.29 g (5.23 mmol) of 70% 3-chloroperbenzoic acid. The mixture was stirred at room temperature for 2 hours, then treated with 25 mL of 10% aq. Na2S2O3 and left to stir for 30 minutes. The reaction was diluted with 100 mL dichloromethane and the phases were separated. The organic phase was washed with 10% aq. K2CO3, brine, and then dried over magnesium sulfate and filtered. Concentration of the filtrate under reduced pressure gave 0.73 g of 7-benzylsulfonyl-3-(2-chlorophenyl)-3,4-dihydropyrimido[4,5-d]-pyrimidin-2(1H)-one as a white solid.

1. temperaturewas cooled in ice
2. waitleft
3. stirringto stir for 30 minutes
4. customthe phases were separated
5. washThe organic phase was washed with 10% aq. K2CO3, brine
6. dry with materialdried over magnesium sulfate
7. filtrationfiltered