Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | Acetone Cyanohydrin | HCID 6406 | — |
| Reactant | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| Reactant | 1-Benzylpiperazine | HCID 75994 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | HCID 22314812 | HCID 22314812 | — |
Reaction Steps
4.5 ml of acetone, 20 g of dry MgSO4, 10 g of N,N-dimethylacetamide, 10 g of 1-benzylpiperazine and 9.5 ml of 2-hydroxyisobutyronitrile are mixed together and heated at 45° C. for 48 hours with vigorous stirring. The reaction mixture is poured onto ice and left stirring for 30 minutes. The mixture is extracted with ether, the organic phase is washed several times with water and dried over Na2SO4, and the solvent is evaporated off under vacuum. 13 g of the expected product are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06642233B1 |
|---|
| Source dataset | uspto-grants-2003_11 |
|---|
| ORD ID | ord-47dd503360ee4b85a53873c7e5d8a5a3 |
|---|
| Source note | uspto-grants-2003_11 |
|---|
