反应详情

A solution of 4-amino-6-chloro-2-(4-methoxyphenyl)methyl-2H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester (800 mg) in NaOH (1N)/MeOH/THF (1:1:1, 15 mL) was stirred for 4 days. The acidity of the reaction mixture was adjusted to pH 5-6 with AcOH. The THF and MeOH were removed. The residue was dissolved in water (30 mL) then extracted with EtOAc (3×100 mL). The combined extracts were dried (NaSO4). Removal of the solvent gave the desired product (746 mg) as white solid. LC: 3.13 (Gradient 1), MH+: 333

1. customThe THF and MeOH were removed
2. dissolutionThe residue was dissolved in water (30 mL)
3. extractionthen extracted with EtOAc (3×100 mL)
4. dry with materialThe combined extracts were dried (NaSO4)
5. customRemoval of the solvent