tert-Butanol → HCID 178458570, compound

Participants

Reaction Conditions

Reaction Steps

To the uncyclized intermediate from example 3 (30 mg) under nitrogen was added K—OtBu (1M, 0.05 mL) and HOtBu (2 mL). The mixture was then heated at 95° C. for 1 h. After cooling to rt, the mixture was subjected to preparative HPLC to give the titled compound (4.5 mg). LC: 3.54′ (Gradient 1); MH+: 634.

Provenance & Evidence