Trifluoroacetic acid → HCID 178458571, compound

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Reaction Steps

A solution of 1-[[3-[5-Chloro-4,8-dihydro-8-[(4-methoxyphenyl)methyl]-4-oxo-1H-pyrazolo[4′,3′:5,6]pyrido[4,3-d]pyrimidin-2-yl]-4-propoxyphenyl]sulfonyl]-4-ethylpiperazine (20 mg) in TFA (8 mL) was heated at 70° C. under nitrogen for 2 h. After cooling to rt, the mixture was subjected to preparative HPLC to give the titled compound (15 mg). LC:2.65′ (Gradient 1); MH+: 514.

Provenance & Evidence