HCID 178458564, compound → HCID 178458565, compound

Participants

Reaction Steps

A solution of (3R)-3-(Dimethylamino)-1-[[3-[5-[[(3-chloro-4-methoxyphenyl)methyl]amino]-4,8-dihydro-8-[(4-methoxyphenyl)methyl]-4-oxo-1H-pyrazolo[4′,3′:5,6]pyrido[4,3-d]pyrimidin-2-yl]-4-propoxyphenyl]sulfonyl]pyrrolidine in TFA (4 mL) was heated at reflux for 1 h. under nitrogen. After removal of the excess TFA, the residue was purified by preparative HPLC to give the desired product (32 mg) as a TFA salt. LC: 3.12 (Gradient 2); MH+: 667.

Provenance & Evidence