Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methyl 4-(4-ethylpiperazin-1-yl)benzoate | HCID 57781922 | — |
| Product | 940284-81-1 | HCID 53523729 | — |
Reaction Steps
4-(4-Ethyl-piperazin-1-yl)-benzoic acid methyl ester (15 mmol) is dissolved in 4N HCl (35 ml) and heated under reflux for 8 hours. The mixture is cooled in an ice bath to 0-4° C. and the solid material formed is filtered off, washed with acetone and dried (vacuum). A grey powder with mp. >270° C., Rf=0.08 (CH2Cl2/MeOH=9:1) is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06642239B2 |
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| Source dataset | uspto-grants-2003_11 |
|---|
| ORD ID | ord-89ac8968c8ce4ca681c975fd2db78a74 |
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| Source note | uspto-grants-2003_11 |
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