HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → Balicatib
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | Diisopropylcarbodiimide | HCID 12734 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 4-(4-propylpiperazin-1-yl)benzoic Acid | HCID 10977812 | — |
| Reactant | 1-Amino-cyclohexanecarboxylic acid cyanomethyl amide | HCID 11194684 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Balicatib | HCID 10201696 | — |
Reaction Steps
In an alternative procedure the acetic acid internal salt of 4-[4-(1-propyl)-piperazin-1-yl]-benzoic acid is treated in acetonitrile with HOBt, NMM and diisopropylcarbodiimide (DICI), and after stirring for 1 hr at 40° C. a solution of 1-amino-cyclohexanecarboxylic acid cyanomethyl-amide in acetonitrile is added. On completion of the reaction, the product is precipitated by addition of water to the reaction mixture, filtered and following digestion with ethanol is dried to the end product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06642239B2 |
| Source dataset | uspto-grants-2003_11 |
| ORD ID | ord-a85f5797bfd64b2dbebaae7c30d0554c |
| Source note | uspto-grants-2003_11 |