HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 478629Generated: October 25, 2026
Acetone → 4-(4-(Propan-2-yl)piperazin-1-yl)benzoic acid hydrochloride
https://huagongshe.com/reaction/478629
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methyl 4-(4-propan-2-yl-piperazin-1-yl)benzoate | HCID 69129778 | — |
| Product | 4-(4-(Propan-2-yl)piperazin-1-yl)benzoic acid hydrochloride | HCID 47002203 | — |
Reaction Steps
4-(4-Isopropyl-piperazin-1-yl)-benzoic acid methyl ester (0.9 mmol) is dissolved in 4N HCl (2 ml) and heated under reflux for 7 hours. The mixture is cooled in an ice bath to 0-4° C. and acetone is added. The solid material formed is filtered off, washed with cold acetone and dried (vacuum). A pale-brown powder with mp. >270° C., Rf=0.08 (CH2Cl2/MeOH=9:1) is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06642239B2 |
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| Source dataset | uspto-grants-2003_11 |
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| ORD ID | ord-cfc40f076cc64d3a88489e8e7a488252 |
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| Source note | uspto-grants-2003_11 |
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