反应详情

4-Piperidin-4-yl-benzoic acid (47 mmol) is dissolved in methanol (300 ml) and 1 ml of concentrated sulfonic acid is added. The mixture is heated under reflux overnight. After evaporation of the solvent, the residue is dissolved in a mixture of water and sodium carbonate (to ensure basic conditions) and extracted three times with ethyl acetate. The combined extract is dried over sodium sulfate and evaporated. A brown powder with Rf=0.18 (CH2Cl2/MeOH=9:1) is obtained.

1. temperatureThe mixture is heated
2. temperatureunder reflux overnight
3. customAfter evaporation of the solvent
4. dissolutionthe residue is dissolved in a mixture of water and sodium carbonate (to ensure basic conditions)
5. extractionextracted three times with ethyl acetate
6. extractionThe combined extract
7. dry with materialis dried over sodium sulfate
8. customevaporated
9. customA brown powder with Rf=0.18 (CH2Cl2/MeOH=9:1) is obtained