反应详情

A stirred solution of (RS)-8-acenaphthen-1-yl-1-phenyl-1,8-diaza-spiro[4.5]decane (50 mg/see example 16) in 3N MeOH—HCl (0.2 ml) was treated with diethyl ether (5 ml). After 1 h the solid was filtered off to yield the desired product (50 mg, 91%) as a pale brown solid, m.p. 195° C and MS: m/e=369.4 (M+H+).

1. filtrationAfter 1 h the solid was filtered off