Fumaric Acid → HCID 86589626, compound

HRID 478663Notes

Reaction equation

HRID 478663 reaction equation
[CH:1]1([N:14]2[CH2:30][CH2:29][C:17]3([N:21]([C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[CH2:20][CH2:19][CH:18]3[OH:28])[CH2:16][CH2:15]2)[C:12]2=[C:13]3[C:8](=[CH:9][CH:10]=[CH:11]2)[CH2:7][CH2:6][CH2:5][CH:4]3[CH2:3][CH2:2]1.[C:31]([O-:38])(=[O:37])/[CH:32]=[CH:33]/[C:34]([O-:36])=[O:35].C(O)(=O)/C=C/C(O)=O>C(OCC)C>[C:31]([OH:38])(=[O:37])/[CH:32]=[CH:33]/[C:34]([OH:36])=[O:35].[CH:1]1([N:14]2[CH2:30][CH2:29][C:17]3([N:21]([C:22]4[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=4)[CH2:20][CH2:19][C:18]3=[O:28])[CH2:16][CH2:15]2)[C:12]2=[C:13]3[C:8](=[CH:9][CH:10]=[CH:11]2)[CH2:7][CH2:6][CH2:5][CH:4]3[CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 444972Fumaric AcidHCID 5460307FumarateHCID 15411839HCID 15411839, compound

Product 1

HCID 86589626HCID 86589626, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Oxidation of 8-(2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl)-1-phenyl-1,8-diaza-spiro[4.5]decan-4-ol (mixture of diastereoisomers) according to the general method of example 20 and formation of the fumarate with fumaric acid in diethyl ether yielded the title compound, pale brown solid, m.p. 144° C. and MS: m/e=401.5 (M+H+).

Sources & evidence

ORD record
ord-41ed69b18c53492caad33b35555f326b
Source dataset
uspto-grants-2003_11
Patent number
US06642247B2

Reaction notes

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