Fumaric Acid → HCID 18002580, compound

HRID 478665Notes

Reaction equation

HRID 478665 reaction equation
[CH2:1]1[CH:10]2[CH:4]([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9]2)[CH2:3][CH:2]1[N:11]1[CH2:27][CH2:26][C:14]2([N:18]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH2:17][CH2:16][CH:15]2[OH:25])[CH2:13][CH2:12]1.[C:28]([O-:35])(=[O:34])/[CH:29]=[CH:30]/[C:31]([O-:33])=[O:32].[C:36](O)(=O)/C=C/C(O)=O>C(OCC)C>[C:28]([OH:35])(=[O:34])/[CH:29]=[CH:30]/[C:31]([OH:33])=[O:32].[CH2:1]1[CH:10]2[CH:4]([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9]2)[CH2:3][CH:2]1[N:11]1[CH2:27][CH2:26][C:14]2([N:18]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH2:17][CH2:16][CH:15]2[O:25][CH3:36])[CH2:13][CH2:12]1

Participants

5

Reactant 3

HCID 444972Fumaric AcidHCID 5460307FumarateHCID 15411835HCID 15411835, compound

Product 1

HCID 18002580HCID 18002580, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Methylation of 8-(decahydro-azulen-2-yl)-1-phenyl-1,8-diaza-spiro[4.5]decan-4-ol (mixture of diastereoisomers) according to the general method of example 31 and formation of the fumarate with fumaric acid in diethyl ether yielded the title compound, white solid, m.p. 260° C. (dec.) and MS: m/e=383.3 (M+H+).

Sources & evidence

ORD record
ord-c2b1bf197ef946a1b54a631b9bd5a7a2
Source dataset
uspto-grants-2003_11
Patent number
US06642247B2

Reaction notes

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