63413-91-2 → HCID 9903765, compound

HRID 478681Notes

Reaction equation

HRID 478681 reaction equation
[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[S:6][CH:7]=[CH:8][C:9]([OH:11])=O.[C:12]1(SC=CC(O)=O)[CH:17]=[CH:16][CH:15]=[CH:14]C=1>>[N:1]12[CH2:14][CH2:15][CH:16]([CH2:17][CH2:12]1)[C@@H:4]([NH:3][C:9](=[O:11])/[CH:8]=[CH:7]/[S:6][C:2]1[NH:1][CH:5]=[CH:4][N:3]=1)[CH2:5]2

Participants

3

Reactant 2

HCID 27570663413-91-2HCID 69943766HCID 69943766, compound

Product 1

HCID 9903765HCID 9903765, compound

Procedure

Employing essentially the same procedure as that described in Example 1 above but substituting 3-(2-imidazolylthio)acrylic acid for the 3-(phenylthio)acrylic acid and purifying by chromatography on silica gel using ammoniated methanol/chloroform mixtures as the eluent resulted in formation of the title compound; MS (ES−) 279. (MH−).

Workup

  1. custompurifying by chromatography on silica gel using ammoniated methanol/chloroform mixtures as the eluent

Sources & evidence

ORD record
ord-e63d1128c164473782818ccc86a23086
Source dataset
uspto-grants-2003_11
Patent number
US06642246B1

Reaction notes

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