HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 6-Methyl-2-(3-nitrophenylamino)nicotinic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 6-Methyl-2-(3-nitrophenylamino)nicotinic acid cyanomethyl ester | HCID 69850253 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 6-Methyl-2-(3-nitrophenylamino)nicotinic acid methyl ester | HCID 69849696 | 97.5% |
Reaction Steps
A mixture of 6-methyl-2-(3-nitrophenylamino)nicotinic acid cyanomethyl ester (15.44 g, 49.43 mmol) and triethylamine (1.00 g, 9.89 mmol) in dry methanol (160 ml) was heated under reflux overnight. After cooling, crystals were collected by filtration, washed with methanol, and dried to give 6-methyl-2-(3-nitrophenylamino)nicotinic acid methyl ester (13.84 g, 97%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06642250B2 |
| Source dataset | uspto-grants-2003_11 |
| ORD ID | ord-13e780f0f6804b45a8771ac4c347675a |
| Source note | uspto-grants-2003_11 |