Benzenamine, 3-(methylthio)- → 6-Methyl-2-(3-methylthiophenylamino)nicotinaldehyde

HRID 478724Notes

Reaction equation

HRID 478724 reaction equation
Cl[C:2]1[N:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH3:12][S:13][C:14]1[CH:15]=[C:16]([CH:18]=[CH:19][CH:20]=1)[NH2:17]>>[CH3:11][C:9]1[CH:8]=[CH:7][C:3]([CH:4]=[O:6])=[C:2]([NH:17][C:16]2[CH:18]=[CH:19][CH:20]=[C:14]([S:13][CH3:12])[CH:15]=2)[N:10]=1

Participants

3

Reactant 2

HCID 15693Benzenamine, 3-(methylthio)-HCID 1217242-Chloro-6-methylnicotinic acid

Product 1

HCID 880211416-Methyl-2-(3-methylthiophenylamino)nicotinaldehyde

Procedure

The procedure of Synthetic Example 1 was repeated using 2-chloro-6-methylnicotinic acid and 3-methylthioaniline to obtain 6-methyl-2-(3-methylthiophenylamino)nicotinaldehyde.

Sources & evidence

ORD record
ord-93bcc640c49e4691840bd47cfc1fd487
Source dataset
uspto-grants-2003_11
Patent number
US06642250B2

Reaction notes

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