HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium diisopropylamide → 1-(3-nitrophenyl)-3-(pyridin-4-ylmethyl)-1,8-naphthyridin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium diisopropylamide | HCID 2724682 | — |
| Reactant | 2-(3-Nitro-phenylamino)-pyridine-3-carbaldehyde | HCID 12114952 | — |
| Reactant | Ethyl isonicotinylacetate | HCID 12229233 | — |
| Product | 1-(3-nitrophenyl)-3-(pyridin-4-ylmethyl)-1,8-naphthyridin-2(1H)-one | HCID 18002652 | — |
Reaction Steps
The procedure of Example 1 was repeated using 2-(3-nitrophenylamino)nicotinaldehyde (1.0 eq.), ethyl 3-(pyridin-4-yl)propionate (1.1 eq.) and LDA (1.5 eq.) to obtain a product which was subjected to recrystallization from ethyl acetate-methanol to give 1-(3-nitrophenyl)-3-(pyridin-4-ylmethyl)-1,8-naphthyridin-2(1H)-one as a pale brown powder, mp 230° C./EtOAc-MeOH (decomp.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06642250B2 |
| Source dataset | uspto-grants-2003_11 |
| ORD ID | ord-5f41c9c1a28c41fd959b40ebef9f9909 |
| Source note | uspto-grants-2003_11 |