HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-(3-pyridyl)butyrate → 1-(3-nitrophenyl)-3-[2-(pyridin-3-yl)ethyl]-1,8-naphthyridin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-(3-pyridyl)butyrate | HCID 152209 | — |
| Reactant | Lithium diisopropylamide | HCID 2724682 | — |
| Reactant | 2-(3-Nitro-phenylamino)-pyridine-3-carbaldehyde | HCID 12114952 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(3-nitrophenyl)-3-[2-(pyridin-3-yl)ethyl]-1,8-naphthyridin-2(1H)-one | HCID 12074620 | — |
Reaction Steps
The procedure of Example 1 was repeated using 2-(3-nitrophenylamino)nicotinaldehyde (1.0 eq.), methyl 4-(pyridin-3-yl)butanoate (1.3 eq., prepared in Synthetic Example 7) and LDA (1.3 eq.) to obtain 1-(3-nitrophenyl)-3-[2-(pyridin-3-yl)ethyl]-1,8-naphthyridin-2(1H)-one, mp 221 to 223° C./DMF, wherein the product was purified through silica gel column chromatography and recrystallization.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06642250B2 |
| Source dataset | uspto-grants-2003_11 |
| ORD ID | ord-522ce04ba2814e3b9b69fb80ccfe67ac |
| Source note | uspto-grants-2003_11 |