HCID 12043201, compound → HCID 20598923, compound

Participants

Reaction Steps

Compound 36 (0.5 g, 1.29 mmol) was dissolved in methanolic ammonia (50 mL, sat. at 0° C.). The reaction mixture was stirred at room temperature for 16 h and evaporated to dryness. The residue was triturated thrice with EtOAc and the solid was crystallized from minimum amount of dry EtOH to yield colorless solid: mp 159-161° C.; 1H NMR (Me2SO-d6) δ3.40-3.52 (m, 2H, C5′H), 3.93 (m, 1H, C4′H), 4.19 (m, 1H, C3′H), 4.46 (m, 1H, C2′H) 4.74, 5.22, 5.62 (m, 3H, 3 OH, D2O exchangeable), 5.84 (d, 1H, J=3.90 Hz, C1′H), 7.95 (br s, 2H) and 9.02 (br s, 2H). Anal. Calc. for C8H13N5O5 (259.22): C, 37.07; H, 5.05; N, 27.02. Found: C, 37.36; H, 5.14; N, 27.01.

Provenance & Evidence