Ethanol → Diethyl 1H-imidazole-4,5-dicarboxylate

HRID 478772Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 478772
[NH:1]1[C:5]([C:6]([OH:8])=[O:7])=[C:4]([C:9]([OH:11])=[O:10])[N:3]=[CH:2]1.[CH2:12](N(CC)CC)[CH3:13].[CH2:19](O)[CH3:20]>ClCCl>[NH:1]1[C:5]([C:6]([O:8][CH2:12][CH3:13])=[O:7])=[C:4]([C:9]([O:11][CH2:19][CH3:20])=[O:10])[N:3]=[CH:2]1

Komponenten

5

Edukt 3

HCID 702EthanolHCID 8471TriethylamineHCID 684421H-Imidazole-4,5-dicarboxylic acid

Produkt 1

HCID 350670Diethyl 1H-imidazole-4,5-dicarboxylateAusbeute 52 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

Imidazole-4,5-dicarboxylic acid (7.55 g, 50.0 mmol) is dissolved in absolute ethyl alcohol (120 mL). The solution was cooled in an ice bath to 0° C. and bubbled dry HCl gas for 1 h. Later, the reaction mixture was refluxed at 80° C. for 7 h during which time all the starting material was consumed. The solvent was removed and the residue that obtained was dissolved in dichloromethane (200 mL) and the organic layer was neutralized with triethylamine. The organic layer was washed with cold water (100 mL) and brine (50 mL), dried over anhydrous sodium sulfate and concentrated in vacuo to give 5.50 g (52%) of white solid: mp 175-177° C.; 1H NMR (CDCl3) δ1.40 (t, 3H), 4.41 (m, 2H), 7.84 (1H, C2H) and 11.55 (br s, 1H, NH).

Aufarbeitung

  1. custombubbled dry HCl gas for 1 h
  2. temperatureLater, the reaction mixture was refluxed at 80° C. for 7 h during which time all the starting material
  3. customwas consumed
  4. customThe solvent was removed
  5. customthe residue that obtained
  6. washThe organic layer was washed with cold water (100 mL) and brine (50 mL)
  7. dry with materialdried over anhydrous sodium sulfate
  8. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-eacb283d896a40578f191fee9c296335
Quelldatensatz
uspto-grants-2003_11
Patentnummer
US06642206B2

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