HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Pyridineacetic acid, hydrochloride (1:1) → N-[(3pyridyl)acetyl]-D,L-alanine iso-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Pyridineacetic acid, hydrochloride (1:1) | HCID 2723724 | — |
| Reactant | 2-Methylpropyl 2-aminopropanoate hydrochloride | HCID 86200109 | — |
| Product | N-[(3pyridyl)acetyl]-D,L-alanine iso-butyl ester | HCID 22492127 | — |
Reaction Steps
Following General Procedure F and using 3-pyridylacetic acid hydrochloride (Aldrich) and D,L-alanine iso-butyl ester hydrochloride (from Example B above), the title compound was prepared as a solid having a melting point of 62°-64° C. The reaction was monitored by tlc on silica gel (Rf=0.48 10% methanol/dichloromethane) and purification was by silica gel chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06642261B2 |
| Source dataset | uspto-grants-2003_11 |
| ORD ID | ord-8496f98db1914fe2af8eeffa27c24c6d |
| Source note | uspto-grants-2003_11 |