3-Thiophenacetic acid → 2-((Thien-3-yl)acetamido]butyric acid iso-butyl ester

HRID 478794Notes

Reaction equation

HRID 478794 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]([CH2:6][C:7]([OH:9])=O)=[CH:2]1.[NH2:10][CH:11]([CH2:19][CH3:20])[C:12]([O:14][CH2:15][CH:16]([CH3:18])[CH3:17])=[O:13]>>[CH2:15]([O:14][C:12](=[O:13])[CH:11]([NH:10][C:7](=[O:9])[CH2:6][C:3]1[CH:4]=[CH:5][S:1][CH:2]=1)[CH2:19][CH3:20])[CH:16]([CH3:17])[CH3:18]

Participants

3

Reactant 2

HCID 234043-Thiophenacetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 542657592-((Thien-3-yl)acetamido]butyric acid iso-butyl ester

Procedure

Following General Procedure I above and using 3-thiopheneacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure J above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Sources & evidence

ORD record
ord-906418ad16084f42b3636f06589a7ead
Source dataset
uspto-grants-2003_11
Patent number
US06642261B2

Reaction notes

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