(2-Hydroxyphenyl)acetic acid → 2-[(2-Hydroxyphenyl)acetamido]butyric acid isobutyl ester

HRID 478797Notes

Reaction equation

HRID 478797 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([OH:11])=O.[NH2:12][CH:13]([CH2:21][CH3:22])[C:14]([O:16][CH2:17][CH:18]([CH3:20])[CH3:19])=[O:15]>>[CH2:17]([O:16][C:14](=[O:15])[CH:13]([NH:12][C:9](=[O:11])[CH2:8][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[OH:1])[CH2:21][CH3:22])[CH:18]([CH3:19])[CH3:20]

Participants

3

Reactant 2

HCID 11970(2-Hydroxyphenyl)acetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 537176952-[(2-Hydroxyphenyl)acetamido]butyric acid isobutyl ester

Procedure

Following General Procedure I above and using 2-hydroxyphenylacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General procedure 3 above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Sources & evidence

ORD record
ord-addd0d946d774848a4e4e5e5f2bb1230
Source dataset
uspto-grants-2003_11
Patent number
US06642261B2

Reaction notes

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