2-Thiophenemethanol → HCID 54552156, compound

HRID 478811Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([NH:11][C@H:12]([C:14]([OH:16])=[O:15])[CH3:13])=[O:10])[CH:5]=[CH:6][CH:7]=1.[S:17]1[CH:21]=[CH:20][CH:19]=[C:18]1[CH2:22]O>>[S:17]1[CH:21]=[CH:20][CH:19]=[C:18]1[CH2:22][O:15][C:14](=[O:16])[C@H:12]([CH3:13])[NH:11][C:9](=[O:10])[CH2:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=1

Participants

Reactant 2

HCID 694672-Thiophenemethanol

HCID 15481783N-(3-chlorophenylacetyl)alanine

Product 1

HCID 54552156HCID 54552156, compound

Procedure

Following General Procedure C above, and using N-(3chlorophenylacetyl alanine (from Example D above) and 2-thiophenemethanol (Aldrich) the title compound can be prepared. The reaction was monitored by tlc on silica gel and purification was by liquid chromatography using 3:7 EtOAc:hexane as the eluant.

Sources & evidence

ORD record: ord-c6804ae147164d37802f8c72a02ead6e
Source dataset: uspto-grants-2003_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06642261B2

Reaction notes

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