L-Alanine ethyl ester → N-[(3,5difluorophenyl)acetyl]alanine Ethyl Ester

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Reaction Steps

Following General Procedure G and using 3,5-difluorophenylacetic acid (Aldrich) and alanine ethyl ester (Aldrich), the title compound was prepared as a solid with a melting point of 93°-95° C. The reaction was monitored by tlc on silica gel (Rf=0.8 in EtOAC) and purification was by chromatography on silica gel using EtOAc as the elulant followed by recrystallization from 1-chlorobutane. NMR data was as follows:

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