Ethyl 3-methylthiazolo(3,2-a)benzimidazole-2-carboxylate → HCID 18003012, compound

Participants

Reaction Steps

Under ice-cooling, 3-methylthiazolo[3,2-a]benzoimidazole-2-carboxylic acid ethyl ester (Can. J. Chem., 45 (23), 2903-2912 (1967) (10 g) was added to THF (250 ml) suspension of LiAlH4 (1.46 g) and stirred at the same temperature for 1 hour. While cooling, the reaction solution was mixed with Na2SO4.10H2O and stirred, and then the insoluble matter was removed by filtration and the solvent was evaporated under a reduced pressure to obtain the title compound (6.36 g).

Provenance & Evidence