HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorobenzyl chloride → 4-Fluoro-2-[(4-fluorophenyl)methyl]phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorobenzyl chloride | HCID 9602 | — |
| Reactant | 4-Fluorophenol | HCID 9732 | — |
| Product | 4-Fluoro-2-[(4-fluorophenyl)methyl]phenol | HCID 22325257 | — |
Reaction Steps
Alkylation of 4-fluorophenol with 4-fluorobenzyl chloride according to the procedure described in J. Chem. Soc, 2431 (1958) gave 4-fluoro-2-(4′-fluorobenzyl)phenol. This material was converted to compound 77, mp 228-230° C., and compound 78, mp 134.5-139° C., by the procedure similar to that in Example 18 method B.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06642268B2 |
| Source dataset | uspto-grants-2003_11 |
| ORD ID | ord-dc5295b64b3c4ba4b081a5fb8573a540 |
| Source note | uspto-grants-2003_11 |