HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Triphenylphosphine → (RS)-4-(2-{3-[(4-cyano-phenylamino)-ethoxycarbonyl-methyl]-5-ethoxy-2-fluoro-phenoxy}-ethyl)-piperidine-1-carboxylic acid tert-butyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Triphenylphosphine | HCID 11776 | — |
| Edukt | ethyl N-ethoxycarbonyliminocarbamate | HCID 220568 | — |
| Edukt | 1-(tert-Butoxycarbonyl)-4-(2-hydroxyethyl)piperidine | HCID 854140 | — |
| Edukt | (RS)-(4-cyano-phenylamino)-(5-ethoxy-2-fluoro-3-hydroxy-phenyl)-acetic acid ethyl ester | HCID 69924374 | — |
| Produkt | (RS)-4-(2-{3-[(4-cyano-phenylamino)-ethoxycarbonyl-methyl]-5-ethoxy-2-fluoro-phenoxy}-ethyl)-piperidine-1-carboxylic acid tert-butyl ester | HCID 69924505 | — |
Reaktionsschritte
In analogy to example 1.5, (RS)-(4-cyano-phenylamino)-(5-ethoxy-2-fluoro-3-hydroxy-phenyl)-acetic acid ethyl ester described in example 1.4 was reacted with 4-(2-hydroxy-ethyl)-piperidine-1-carboxylic acid tert-butyl ester, diethyl azodicarboxylate and triphenylphosphine to give (RS)-4-(2-{3-[(4-cyano-phenylamino)-ethoxycarbonyl-methyl]-5-ethoxy-2-fluoro-phenoxy}-ethyl)-piperidine-1-carboxylic acid tert-butyl ester as a colorless solid. MS: 570.2 ([M+H]+).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06642386B2 |
| Quelldatensatz | uspto-grants-2003_11 |
| ORD ID | ord-affb54998e6242a2935cb1dcfbaecc92 |
| Quellennotiz | uspto-grants-2003_11 |