Acetic Acid → HCID 18003373, compound

Participants

Reaction Steps

A solution of 340 mg (RS)-(4-carbamimidoyl-phenylamino)-[5-ethoxy-2-fluoro-3-(1-methyl-piperidin-4-ylmethoxy)-phenyl]-acetic acid ethyl ester acetate in 5 ml THF was treated with 2.8 ml 1N LiOH and stirred at room temperature for 2 hours. The reaction mixture was neutralized with acetic acid and evaporated in vacuo. The residue was stirred in 1.5 ml of water. Suction filtration and drying gave 173 mg (RS)-(4-carbamimidoyl-phenylamino)-[5-ethoxy-2-fluoro-3-(1-methyl-piperidin-4-ylmethoxy)-phenyl]-acetic acid. Mp.: 232° C. Light brown solid. MS: 459 ([M+H]+).

Provenance & Evidence