HRID478967

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID643502

n-boc-4-hydroxypiperidine

C10H19NO3

结构：CCOC(=O)C(Nc1ccc(C#N)cc1)c1cc(OCC)cc(O)c1F

HCID69924374

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)C(Nc1ccc(C#N)cc1)c1cc(OCC)cc(OC2CCN(C(=O)OC(C)(C)C)CC2)c1F

HCID69923731

未命名化合物

PROCEDURE

实验过程

In analogy to example 1.5, (RS)-(4-cyano-phenylamino)-(5-ethoxy-2-fluoro-3-hydroxy-phenyl)-acetic acid ethyl ester described in example 1.4 was reacted with 1-tert-butyloxycarbonyl-4-hydroxy-piperidine to give (RS)-4-{3-[(4-cyano-phenylamino)-ethoxycarbonyl-methyl]-5-ethoxy-2-fluoro-phenoxy}-piperidine-1-carboxylic acid tert-butyl ester. MS: 559.5 ([M+H]+).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-dd9c7c02636c412fad5fbd41eb3ac9e6
来源数据集: uspto-grants-2003_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06642386B2
来源说明: uspto-grants-2003_11

反应 SMILES

[CH2:1]([O:3][C:4](=[O:26])[CH:5]([NH:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]#[N:25])=[CH:20][CH:19]=1)[C:6]1[CH:11]=[C:10]([O:12][CH2:13][CH3:14])[CH:9]=[C:8]([OH:15])[C:7]=1[F:16])[CH3:2].[C:27]([O:31][C:32]([N:34]1[CH2:39][CH2:38][CH:37](O)[CH2:36][CH2:35]1)=[O:33])([CH3:30])([CH3:29])[CH3:28]>>[C:27]([O:31][C:32]([N:34]1[CH2:39][CH2:38][CH:37]([O:15][C:8]2[CH:9]=[C:10]([O:12][CH2:13][CH3:14])[CH:11]=[C:6]([CH:5]([NH:17][C:18]3[CH:19]=[CH:20][C:21]([C:24]#[N:25])=[CH:22][CH:23]=3)[C:4]([O:3][CH2:1][CH3:2])=[O:26])[C:7]=2[F:16])[CH2:36][CH2:35]1)=[O:33])([CH3:30])([CH3:28])[CH3:29]