Hydrochloric Acid → HCID 140461950, compound

Participants

Reaction Steps

A solution of 2.3 g (RS)-[4-(tert-butoxycarbonylamino-imino-methyl)-phenylamino]-[5-ethoxy-2-fluoro-3-(1-methyl-piperidin-4-yloxy)-phenyl]-acetic acid ethyl ester in 23 ml ethanol was treated with 6.06 ml 1N sodium hydroxyde solution. After one hour, 2.6 ml 1N hydrochloric acid were added until pH=8. The solvent was evaporated and the residue dried to constant weight. It was dissolved in absolute ethanol, filtered, the solution evaporated in vacuo, the residue dried and triturated in ether to yield 2.3 g of (RS)-[4-(tert-butoxycarbonylamino-imino-methyl)-phenylamino]-[5-ethoxy-2-fluoro-3-(1-methyl-piperidin-4-yloxy)-phenyl]-acetic acid.off-white solid. MS: 545 ([M+H]+).

Provenance & Evidence