HCID 18003361, compound → HCID 18003354, compound

Participants

Reaction Steps

215.9 g (0.85 moles) of 3-[2-(3,3,5,5-tetramethyl-2-oxo-piperazin-1-yl)-ethoxy]-propionitrile are dissolved in 900 m of methanol and hydrogenated at 120° C. and at 50 bars in the presence of 100 g of Ni Raney as catalyst. The mixture is then filtered and the organic phase is evaporated under vacuum (40° C./1 0 mbar). The residue is distilled giving a white oil b.p. 130-136OC./0.8 mbar.

Provenance & Evidence