Potassium sodium tartarate → HCID 11229784, compound

Participants

Reaction Steps

Into toluene (15 ml) was added (R)-2-phenyl-2-(3,4,5,6-tetrahydro-[2H]-pyran-2-yloxy)mandelic acid methyl ester (7.0 g) obtained in 2) above, and thereto was dropwise added a 70% sodium dihydrobis(2-methoxyethoxy)aluminate toluene solution (8.73 g) with ice cooling. The resulting mixture was stirred at the same temperature for 1 hour, the reaction mixture was added into a 30% aqueous (+)−potassium sodium tartrate solution (31.3 g), then stirred for 1 hour, and the organic layer was separated. The organic layer obtained was washed with water and further with a saturated aqueous sodium chloride solution and then dried with anhydrous magnesium sulfate. The desiccant was removed by filtration and the solvent was distilled off to obtain a colorless oily compound mentioned above (6.10 g, 97.9%).

Provenance & Evidence