Hydrochloric Acid → 1,2-Ethanediol, 1-phenyl-, 2-methanesulfonate, (1R)-

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Reaction Steps

Into methanol (10 ml) were added (R)-2-phenyl-2-(3,4,5,6-tetrahydro-[2H]-pyran-2-yloxy)ethyl methanesulfonate (2.0 g) and hydrochloric acid (0.07 g), and the resulting mixture was stirred at room temperature for 3 hours. The reaction mixture was neutralized, concentrated, and then ethyl acetate and water were added to the resulting residue. The organic layer was collected by layer separation, washed with a saturated aqueous sodium chloride solution and dried with anhydrous magnesium sulfate. The desiccant was filtered off and then the solvent was distilled off to obtain a colorless oily compound mentioned above (1.4 g, 97.2%).

Provenance & Evidence