反应详情

120 g of 3-bromo-2,4-dichloro-5-fluoronitrobenzene (0.415 mol), 1.66 g of NaOH (0.042 mol) and 26.9 g of sodium methoxide (0.498 mol) in 500 ml of methanol were stirred at 60° C. for 4 hours. The reactant was extracted with ethyl ether, washed successively with water, dilute hydrochloric acid solution, and water, dried over anhydrous sodium sulfate, and evaporated. The residue was recrystallized from ethanol to give 73.5 g of 2,4-dichloro-5-fluoro-3-methoxynitrobenzene (0.306 mol) in 73.8% yield.

1. extractionThe reactant was extracted with ethyl ether
2. washwashed successively with water, dilute hydrochloric acid solution, and water
3. dry with materialdried over anhydrous sodium sulfate
4. customevaporated
5. customThe residue was recrystallized from ethanol