HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4-Dichloro-5-fluoro-3-methoxynitrobenzene → 2,4-Dichloro-5-fluoro-3-methoxyaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4-Dichloro-5-fluoro-3-methoxynitrobenzene | HCID 23431779 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2,4-Dichloro-5-fluoro-3-methoxyaniline | HCID 23431789 | 93% |
Reaction Steps
72.0 g of 2,4-dichloro-5-fluoro-3-methoxynitrobenzene (0.30 mol) and 2.65 g of Pd/C in 500 ml of methanol were hydrogenated under 3 Mpa (hydrogen pressure) at 60° C. for 3 hours. The reactant was cooled to room temperature. The catalyst was filtered out, and the solvent was evaporated to give 58.5 g of 2,4-dichloro-5-fluoro-3-methoxyaniline (0.279 mol) in 92.9% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06699992B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-626062908a0840f4a6078593e9cd23c7 |
| Source note | uspto-grants-2004_03 |