HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Dichloro-3-fluoro-5-nitrobenzonitrile → 3-Cyano-2,4-dichloro-5-fluoroaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Dichloro-3-fluoro-5-nitrobenzonitrile | HCID 23431795 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-Cyano-2,4-dichloro-5-fluoroaniline | HCID 23431778 | — |
Reaction Steps
27.0 g of 3-cyano-2,4-dichloro-5-fluoronitrobenzene (0.247 mol), 500 ml of ethanol and 2.18 g of Pd/C were heated to 60° C. and hydrogenated under 3 Mpa of hydrogen pressure for 3 hours. The reaction mixture was cooled to room temperature. The catalyst was filtered off. After removing the solvent, 48.0 g of 3-cyano-2,4-dichloro-5-fluoroaniline were given in 94.7 yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06699992B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-4bc98b06321d4f47a6ecc41e0e945a1c |
| Source note | uspto-grants-2004_03 |