Acetonitrile → HCID 69782454, compound

Participants

Reaction Steps

The above compound was also prepared in a similar manner, but using acetonitrile without addition of water, from 3-cyclopropyl-2-ethoxycarbonyl-1-(4-fluoro-3-methoxy-2-methylthiophenyl)propane-1,3-dione. In this experiment the reaction mixture was heated for 20 hours at reflux, resulting in a clean conversion to the title compound (as shown by nmr), but after this time 60% of the starting ethyl ester still remained.

Provenance & Evidence