Methyl iodide → 6-Methylthio-pyrimidine-2,4-diamine

Participants

Reaction Steps

To a stirred solution of 105 g KOH in 1 L of water was added 2,4-diamino-6-mercaptopyrimidine hemisulfate 1 (70.0 g) followed by methyl iodide (91 mL). The resulting mixture was vigorously stirred for 4 h and then the solid precipitate was filtered off, washed with water and air dried overnight to give 54.0 g of 6-Methylthio-pyrimidine-2,4-diamine as a tan colored solid.

Provenance & Evidence