反应详情

0.184 g of 2-Methoxy-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzo[b]thiophen-7-yl}-propionic acid ethyl ester (0.40 mmol) was dissolved in 1 ml of THF/MeOH=1/1 and treated with 0.670 ml of 3N NaOH. The reaction mixture was kept over night at RT and then quenched by pouring onto crashed ice/HCl. Twofold extraction with AcOEt, washing with water, drying over sodium sulfate, and evaporation of the solvents left a crude product, which was purified by crystallisation from AcOEt/hexane to yield 0.158 g of the title compound as white solid, mp.121-122°.

1. waitThe reaction mixture was kept over night at RT
2. customquenched
3. additionby pouring
4. extractionTwofold extraction with AcOEt
5. washwashing with water
6. dry with materialdrying over sodium sulfate, and evaporation of the solvents
7. waitleft a crude product, which
8. customwas purified by crystallisation from AcOEt/hexane