反应详情

温度

55 °C

Carvedilol (4 g) was dissolved in 45 mL of a mixture of 96% Ethanol and 4% water by heating the mixture under stirring in a 55° C. water bath. The solution was cooled and left at room temperature without stirring for about 14 hours, the crystals were filtered through a buchner funnel, rinsed twice with about 10 ml cold (4° C.) 96% ethanol, and dried in a desiccator at room temperature (connected to air pump) until constant weight to yield carvedilol Form III.

1. temperatureby heating the mixture
2. temperatureThe solution was cooled
3. waitleft at room temperature
4. stirringwithout stirring for about 14 hours
5. filtrationthe crystals were filtered through a buchner funnel
6. washrinsed twice with about 10 ml cold (4° C.) 96% ethanol
7. customdried in a desiccator at room temperature (connected to air pump) until constant weight