Sodium Hydroxide → HCID 18003589, compound

Participants

Reaction Steps

0.142 g of the above prepared [rac]-3-(4-{2-[2-(3,5-dichloro-phenyl)-5-methyl-oxazol-4-yl]-ethoxy}-benzo[b]thiophen-7-yl)-2-methoxy-propionic acid ethyl ester (0.27 mmol) was dissolved in 4 ml of THF/EtOH=1/1 and treated with 0.68 ml of 1N NaOH (2.5 eq.). The reaction mixture was stirred at ambient temperature and progress of the hydrolysis followed by TLC. After 2 h, the reaction mixture was poured onto crashed ice/HCl dil. and extracted twice with AcOEt. The organic layer was washed with water and brine, dried over magnesium sulfate, and evaporated to dryness. Crystallization from AcOEt/hexane yielded finally 0.107 g of the title product as white crystals of mp. 160-61°.

Provenance & Evidence