反应详情

10.56 g of the above prepared 2-(4-methoxy-benzoylamino)-pent-4-enoic acid ethyl ester (38.1 mmol) was dissolved in 120 ml of THF/EtOH=1/1 and treated at 0° with 38 ml of 2N NaOH. The reaction mixture was kept at this temperature for 3 h. It was then poured onto crashed ice/HCl, extracted twice with AcOEt, washed with brine, and dried over natrium sulfate. Evaporation of the solvents, followed by crystallisation from AcOEt at −20°, yielded 8.41 g of the title acid as white crystals of m.p. 121-124°.

1. additionIt was then poured
2. extractionextracted twice with AcOEt
3. washwashed with brine
4. dry with materialdried over natrium sulfate
5. customEvaporation of the solvents
6. customfollowed by crystallisation from AcOEt at −20°
7. customyielded 8.41 g of the title acid as white crystals of m.p. 121-124°