HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → HCID 18003572, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Bromoacetic Acid | HCID 6227 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Ethyl isopropoxyacetate | HCID 537908 | — |
| Reactant | (s)-2-But-3-enyloxy-3-(4-{2-[2-(4-isopropyl-phenyl)-5-methyl-oxazol-4-yl]-ethoxy}-benzo[b]thiophen-7-yl)-propionic acid | HCID 69556375 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 18003572 | HCID 18003572 | — |
Reaction Steps
was prepared in analogy to example 39, but using in the aldol-coupling step ethyl isopropoxy-acetate instead of butyl butoxy-acetate as white crystals of mp. 148-150°. The former reagent was synthesized as described above for but-3-enyloxy-acetic acid (see example 65) from iPrOH, NaH, and bromo-acetic acid, followed by acid catalyzed esterification with EtOH.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06642389B2 |
| Source dataset | uspto-grants-2003_11 |
| ORD ID | ord-1d3e39c5ea0a4de897ae8f9539fa04a3 |
| Source note | uspto-grants-2003_11 |