HCID 69557136, compound → HCID 10272779, compound

Participants

Reaction Steps

To a solution of 0.40 g of 2Z-ethoxy-3-{2-methyl-4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-acrylic acid ethyl ester in 10 ml of THF, 5 ml of MeOH and 5 ml of water was added at 22° C. 0.116 g of LiOHxH2O and stirring was continued for 2 d. The yellow solution was evaporated, the residue dissolved in 20 ml of water and the pH was adjusted to 5 using ca. 2.6 ml of 1 N aqueous HCl. The suspension was filtered, the residue washed with water and dried to give 0.34 g (91%) of the title compound as a white solid.

Provenance & Evidence