5,6,7,8-Tetrahydro-1-naphthol → HCID 18003621, compound

Participants

Reaction Steps

In analogy to the procedures described in examples 91 a] and b] 5,6,7,8-tetrahydro-naphthalen-1-ol was reacted with methanesulfonic acid 2-(5-methyl-2-phenyl-oxazol-4-yl)-ethyl ester [PCT Int. Appl. (2000) WO0008002] to give 5-methyl-2-phenyl-4-[2-(5,6,7,8-tetrahydro-naphthalen-1-yloxy)-ethyl]-oxazole. Treatment of 5-methyl-2-phenyl-4-[2-(5,6,7,8-tetrahydro-naphthalen-1-yloxy)-ethyl]-oxazole with dichloromethyl methyl ether and titanium tetrachloride then gave 4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-5,6,7,8-tetrahydro-naphthalene-1-carbaldehyde as yellow solid.

Provenance & Evidence